In my my TFE-X I have 3 modules: Vanilla, 6.0.1 and the KOTB demo. I played 6.0.1 almost to the end, then activated the demo, played for a bit, then reactivated 6.0.1. Now my first two character portraits just show a picture of a mouse pointer. Edit: let me guess...portrait packs?
Yes. If you installed a portrait pack, you need to reinstall it if you deactivate/reactivate a module.