When I talk to Ophelia (it doesn't matter which character I use, or whether they are male or female), I get two options: 1. I've come the wrong way. I'll be heading out then. 2. I'm still working on finding out about Jenelda for you. Both options end the dialogue. If I talk to any of the girls in the brothel, they all tell me to go talk to Ophelia first, including Jenelda. The only person I can talk to even a little bit is Riana; I can offer to talk to Ophelia on her behalf, but this doesn't change Ophelia's dialogue. The "Madam Ophelia's Weakest Link" quest is "Mentioned" in my journal, but I can't make progress on it. I seem to have stumbled into an untenable situation with this quest line. If it matters, I'm using a Neutral Good party. I don't have any paladins. Co8 version 8.1.0 New Content Edition, Temple+ 1.0.75.
Any interaction there is blocked for Lawful Good parties, are you sure that you chose Neutral Good for the party alignment?
