Human Genome project discussion

Discussion in 'General Discussion' started by Sergio Morozov, Apr 17, 2011.

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  1. Sergio Morozov

    Sergio Morozov Paladin

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    http://en.wikipedia.org/wiki/Human_genome
    ...
    A personal genome sequence is a complete sequencing of the chemical base pairs that make up the DNA of a single person. Because medical treatments have different effects on different people because of genetic variations such as single-nucleotide polymorphisms (SNPs), the analysis of personal genomes may lead to personalized medical treatment based on individual genotypes.[citation needed]

    The completion of the fifth such map was announced in December 2008. The genome mapped was that of a Korean researcher Seong-Jin Kim. Genome maps had previously been completed for Craig Venter of the U.S. in 2007, James Watson of the U.S. in April 2008, and Yang Huanming of China in November 2008 and Dan Stoicescu in January 2008.[20][21][22]

    Personal genomes had not been sequenced in the Human Genome Project to protect the identity of volunteers who provided DNA samples. That sequence was derived from the DNA of several volunteers from a diverse population.[23] Another distinction is that the HGP sequence is haploid, however, the sequence maps for Venter and Watson for example are diploid, representing both sets of chromosomes.

    Kim’s genome had 1.58 million SNPs that had never been reported before and indicates that six out of 10,000 DNA bases are unique to Koreans. Kim's sequence map can be used to assist in building a standard Korean genome, which can then be used to compare the genomes of other Korean individuals for personalized medical treatments.
    ...

    So, as I've said in now-lost off-topic post in SPACEMAN, there are no accurate and sufficiently broad studies of "ethnic" human genome - read this - they have studied just ONE Korean and made a conclusion, that ALL Koreans have some unique-to-Koreans genes. They even placed this into the wiki. Come on, this is like looking into my eyes and concluding, that all Russians have grey-blue eyes, and this is silly (to conclude this, not to have grey-blue eyes... well, maybe that too...)
     
    Last edited: Apr 17, 2011
  2. stage

    stage Member

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  3. kio11

    kio11 Established Member

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  4. Rocktoy

    Rocktoy Established Member

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    I think you missed the point. One does not need to track down whole human genome, in order to track down human heritage. Just the markers of mitochondrial DNA are sufficient. What comes to the tracking down of European genetically relativity, the Union funded a research that sucked a lot of our funds and proved only what we already knew:
    http://bigthink.com/ideas/21358
     
  5. Sergio Morozov

    Sergio Morozov Paladin

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    From the "MAP" it can be seen that MORE THAN HALF OF EUROPE WAS IGNORED in the research, yet the map is called "Genetic map of the Europe". Yes, my friend, I am speaking of three Baltic republics (Lithuania, Estonia, Latvia), of Ukraine and Belarus, and, of course, of Russia, which covers half of the Europe and has a lot of different nationalities living in it. Oh, and there is that little part of Turkey.

    But, even if they would call this map "The Genetic Map of Lesser Half of Europe", I would not "believe" them until I've read their article describing how many people were tested etc. And, as in many such studies, they had probably tested too few. I do not know though, but come on, they forgot the larger half of the object of their study, what kind of accuracy could we expect from them?

    [EDIT] Hey, I've just remembered, Finland has several distinct nationalities too, why is there one "blob" for it on the map? This alone may ruin any faith in this research.

    [EDIT] Read this: "Yugoslav genetic variation is quite large (hence the big pink blob), and overlaps with the Greek, Romanian, Hungarian, Czech and even the Italian ones." Excuse me, what century was this research carried out in? Even better, were there any "Yugoslav" sometime ever? Come on, that was a state, not a nation, no wonder that if you mix results for a dozen of different nations, you get "the big pink blob"...

    [EDIT] I've read the numbers. Testing 2500 people is good, but I do not think it is good for an area having hundreds of millions of people. On the average they have tested ~100 people from each "ethnic group". It is also suspicious that they only used "selected" results, not all of them. And it is still unclear how much "creativity" did they pour into compiling the map.
     
    Last edited: Apr 22, 2011
  6. Rocktoy

    Rocktoy Established Member

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    Well the study was funded and conducted by the EU in order to prove some paneuropean dream of paneuropean
    relation, in order to override the local nationalalist thoughts. Shortly, to prove that we who are in EU: are just members of one huge happy family.
    I do not know if the Baltic States were members of EU when the study began and it is highly debatable if Ukraine and Belarus are even part of so-called European subcontinent. Given that, do you really think that European Union scientist mapping European heritage would have even included in their study countries such as Belarus or Ukraine, given that they are not members of the Union, or would the scientist even be welcomend in such countries? Not to mention Russia or Turkey, which have geographically only a minuscule land inside so-called European subcontinent?
    Google it or check the official EU research site (which is nothing but a maze). If I recall correctly they tested several thousand subjects in each country and it took some years to finish the study. (but as I said, it is not my field of expertise, so I must rely on the information given by the media or the university intranet.)

    Where the heck did you come up with that? According to the given genetical map: western fins (which I am) are further genetically relatives with the eastern fins, than the French are with the English. There are three ethnic entities ( west, east and north) in Finland, but they can hardly be called as nationalities: as they all speak the same language and live by the same culture.
     
    Last edited: Apr 29, 2011
  7. Sergio Morozov

    Sergio Morozov Paladin

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    http://en.wikipedia.org/wiki/Ethnic_issues_in_Finland

    Language (people in 2010)
    Finnish 4,856,529
    Swedish 265,982
    Sami 1,832
    Other: 222,926
    Russian 54,546
    Estonian 28,355
    Somali 12,985
    English 12,758
    Arabic 10,379

    Yea, yea, you are right, I thought, somehow, that Sami people were more numerous. (Although this is statistics by language, maybe some of them speak Finnish...)

    As for the number of people tested, I've found it, there is an [EDIT] part in my long previous post.
     
  8. Sergio Morozov

    Sergio Morozov Paladin

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    Uh-oh, look at the map from http://en.wikipedia.org/wiki/Continents :)

    Also from here http://en.wikipedia.org/wiki/Western_Russia

    Europe 10.180.000 square kilometers
    European part of Russia 3.960.000 square kilometers
    So, it is 39% of Europe.

    Now, if we include other countries we have discussed...

    Belarus 207.600
    Ukraine 603.628
    Lithuania 65.200
    Latvia 64.589
    Estonia 45.228

    Total 4.847.000 square kilometers... Or 49% of Europe... Ok, still did not break the 50% threshold, but I did not consider Turkey or Kazakhstan yet...

    [EDIT] OH, no! How could I miss the mighty republic of MOLDOVA !!!

    :D
     

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    Last edited: Apr 29, 2011
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